Impact of Ketogenic diet on aging associated gene expression in the brain.

The Ketogenic Diet (KD) was shown to extend lifespan and preserve memory in aged mice. We carried out RNA-seq on brains of mice aged 13-26 months on standard Carbohydrate-rich control Diet (CD) vs KD, to better understand KD's mechanism for memory preservation. At 12 months of age, mice were randomized to control or ketogenic diet. Animals were harvested at 13 and 26 months of age.