The role of somatic mutations in complex diseases, including neurodevelopmental and neurodegenerative disorders, is becoming increasingly clear. However, to date, no study has shown their relation to
Normal epidermis surrounding a lesion will be collected from consenting donors. The epithelia is removed from the dermis and cut into mapped 2mm2 pieces and DNA extracted. The DNA undergoes ultra-de
As we age, our cells accumulate mutations, termed "somatic mutations". Somatic mutations, which exist in mosaic form throughout the body, are a direct record of the evolution of our cells. Some of the