LUMICAN MODULATES ADIPOCYTE FUNCTION IN OBESITY-ASSOCIATED TYPE 2 DIABETES
收藏Taylor & Francis Group2022-12-12 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/LUMICAN_MODULATES_ADIPOCYTE_FUNCTION_IN_OBESITY-ASSOCIATED_TYPE_2_DIABETES/21665598/1
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资源简介：
Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from subjects with and without DM, we studied lumican effects on adipocyte function. Lumican was increased in VAT and adipocytes in DM. Lumican knockdown in adipocytes decreased lipolysis and improved adipogenesis and insulin sensitivity in VAT adipocytes in DM, while treatment with human recombinant lumican increased lipolysis and impaired insulin-sensitivity in an ERK-dependent manner. We demonstrate that lumican impairs adipocyte metabolism, partially via ERK signaling, and is a potential target for developing adipose tissue-targeted therapeutics in DM.
提供机构：
Lumeng, Carey N.; Flesher, Carmen G.; Eichler, Tad; Strieder-Barboza, Clarissa; Ehlers, Anne P.; O’Rourke, Robert W.; Ky, Alexander; Akinleye, Olukemi; Geletka, Lynn M.
创建时间：
2022-12-02
