Innovative Approaches for Minor Consent: Consent 2.0

ATN 150 examined how parental involvement in the consent process affects the acceptability of hypothetical participation in biomedical HIV prevention trials from the perspectives of minor adolescents and parents. The quasi-experimental design involved a simulated consent process for two HIV prevention trials to assess minors' willingness to participate (WTP) in such trials with varying degrees of parental involvement. The three consent conditions were minor self-consent, adult permission required, and parental permission required. Adolescents were randomized to one of these three consent conditions. Parents underwent a similar simulated consent process and rated the acceptability of all three consent conditions. No effect of consent condition on adolescent WTP in biomedical HIV prevention trials was found. There were significant differences in the acceptability of the consent conditions from the perspectives of parents with parental permission required most acceptable.