Precision Imaging Parkinson's disease (PIPD) dataset

Dataset description:Patients. A total of 180 PD patients were recruited from Henan Provincial People’s Hospital (HPPH), China. The inclusion criteria included being aged 18 years or above and a clinically diagnosed PD. Exclusion criteria comprised the following: (a) MRI contraindications; (b) a history of neurological disorders aside from PD, including stroke, cerebrovascular disease, seizures, and brain tumors; (c) prior invasive neurosurgeries such as DBS or ablation; and (d) average relative head motion larger than 0.2 mm during rsfMRI scanning. Four patients did not complete MRI scanning, and 10 patients were excluded due to excessive head motion. Ultimately, 166 patients were included in the analysis (64 women, 102 men; mean age = 61.8 ± 7.84 (mean ± std.) years.Healthy controls. 71 healthy participants aged 18 years or older, devoid of neurological or psychiatric disorders, were enrolled. Exclusion criteria included MRI contraindications and an average relative head motion exceeding 0.2 mm. After excluding 11 participants due to excessive head motion, the analysis included 60 healthy control participants (34 women, 26 men; mean age = 56.10 ± 6.64 years. The control group exhibited significantly different demographics from the PD group. We thus sampled a subset of 65 PD patients from the 166 patients to ensure demographic matching when performing case-control analyses. The experimental protocol was approved by the HPPH Institutional Review Board (IRB). Written informed consent was obtained from all participants.MRI acquisition. Participants underwent one structural MRI scan lasting 8 minutes and 50 seconds, and five  scans, each spanning 6 minutes and 14 seconds, resulting in a cumulative scan duration of 31 minutes and 10 seconds. MRI was performed using a Siemens 3T Prisma MRI scanner equipped with a 64-channel head coil. The structural scans involved T1-weighted images acquired through a MP2RAGE sequence (TI1 = 755 ms, TI2 = 2500 ms, TE = 3.43 ms, TR = 5,000 ms, flip angle1 = 4°, flip angle2 = 5°, matrix size = 256 ×256, 208 sagittal slices, spatial resolution = 1 × 1 × 1 mm3). An acceleration factor of 3 (with 32 reference lines) was applied in the primary phase encoding direction, with online GRAPPA image reconstruction. RsfMRI data were acquired using a gradient-echo echo planar imaging (GE-EPI) sequence (TE = 35 ms, TR = 2,000 ms, flip angle = 80º, and 75 slices, spatial resolution = 2.2 × 2.2 × 2.2 mm3). During data acquisition, participants were instructed to maintain their eyes open, remain awake while keeping their body still, and minimize head movement.