Mus musculus strain:C57BL/6J | breed:laboratory mouse Raw sequence reads

PLN-R14del is a pathogenic Phospholamban gene variant, characterized by ventricular arrhythmias and dilated cardiomyopathy in heterozygous carriers. Disease development is highly heterogeneous, indicating involvement of additional disease triggers, influencing both the onset and severity of the disease. Here, a heterozygous PLN-R14del mouse model with late-onset disease was used to investigate whether cardiac pressure overload induced stress, could accelerate disease onset.