Role of gut microbiota in diphenylcyclopropenone-evoked chronic itch in mice with or without novel object recognition-related cognitive dysfunction

We attempted to investigate the role of gut microbiota in diphenylcyclopropenone (DCP)-evoked chronic itch in mice and hierarchical cluster analysis of novel objectrecognition test (ORT) results were used to classify DCP-evoked itch model mice with or without cognitive dysfunction (CD)-like phenotype, and 16S ribosomal RNA (rRNA) gene sequencing was used to compare gut bacterial composition between CD (Susceptible)and Non-CD phenotypes (Unsusceptible) in chronic itch mice.