Sc3+-Catalyzed Aldol-Type Additions of N-Benzoylcyclopropanecarboxamides via Iodide-Mediated Ring-Opening: Stereoselective Synthesis of γ-Lactams
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资源简介：
A new catalytic aldol-type addition of cyclopropanecarboximides to aldehydes via iodide-mediated ring-opening is presented. The reaction was found to be catalyzed at 0 °C using either a Sc(OTf)3/NaI system or ScI3. Stereoselective formation of α,α-disubstituted enolates occurred in situ. γ-Lactams bearing α-carbonyl quaternary stereocenters were obtained in 97−57% yield and dr = 90:10−80:20 after ring closure.
创建时间：
2008-04-17
