TLR9

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017]

该基因编码的蛋白质属于Toll样受体（TLR）家族，该家族在病原体识别和固有免疫激活中发挥着根本性作用。TLR从果蝇到人类均表现出高度保守性，且在结构和功能上具有相似性。它们识别感染性病原体上表达的病原体相关分子模式（PAMPs），并介导生成细胞因子，这些细胞因子对于有效免疫的发展至关重要。小鼠和人类的研究表明，该受体介导细胞对细菌DNA中未甲基化的CpG二核苷酸的反应，以启动固有免疫反应。 [由RefSeq提供，2017年8月]