MicroRNA signature in plasma-derived extracellular vesicles in Frontotemporal Dementia

The database includes the raw data of the article “MicroRNA signature in plasma-derived extracellular vesicles in Frontotemporal Dementia”. This work aimed to to find a miRNA signature that could be employed to characterize FTD pathology. The database includes data obtained by the following investigations: a) patients’ clinical evaluation; b) miRNAs expression level in EVs; c) miRNAs expression level in PBMCs; d) miRNAs-target-genes expression level in PBMCs. Mir-365a-3p and miR-212 were found to be down-deregulated in FTD and together with their target genes (CCNB1, FOXO3a, CCND1, SHC1) they are involved in the cell cycle and apoptotic pathways suggesting a potential role in the pathological process that occurs in FTD.