Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the microglia receptor TREM2 increase AD risk and activation of âdisease-associated microgliaâ (DAM) is dependent on
BackgroundThe astrocytic phospholipase A2 (PLA2)-arachidonic acid (AA) pathway is crucial in understanding the reduction of cerebral blood flow (CBF) prior to cognitive deterioration. In complementary
IntroductionWestern diet (WD)-induced visceral adipose tissue (VAT) inflammation is characterized by adipocyte hypertrophy, hypoxia, and apoptosis. Epididymal white adipose tissue (eWAT), a representa
Exercise confers cognitive benefits in Alzheimer's disease (AD), yet the underlying mechanisms remain incompletely understood. The skeletal muscle functions as an endocrine organ that secretes myokine
