Alterations in chromosome spatial compartmentalization classify prostate cancer progression [array]. Alterations in chromosome spatial compartmentalization classify prostate cancer progression [array]

Through a systematic analysis of chromosome conformation capture in a cohort of cells that model cancer progression, San Martin et.al. find that rearrangement of the 3D genome structure in prostate cancer is a potential mechanism for disease exacerbation and that genome-wide compartment identity can classify cancer according to progression Overall design: Analysis of the gene expression of a cohort of cell lines in the continuum of prostate cancer, from adenocarcinoma to bone metastatic