Linezolid-resistant staphylococci. Staphylococcus spp.
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA419124
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资源简介：
Staphylococcus aureus and coagulase negative staphylococci (CoNS) now represent one of the major nosocomial pathogens. Therapeutically, both S. aureus and CoNS are challenging due to the large proportion of multidrug resistant strains. Thus, oxazolidinones are last resort antimicrobial molecules to treat CoNS infections. Using whole genome sequencing we have investigated a selection of methicillin and linezolid-resistant (LR) recent clinical isolates from infected patients. In these isolates, the linezolid resistance was caused by (i) mutations in the chromosome-located genes encoding the 23S RNA and L3 and L4 ribosomal proteins.
创建时间：
2017-11-20
