BET bromodomain inhibition rescues PD-1-mediated T cell exhaustion in acute myeloid leukemia

We report that the bromodomain and extraterminal domain (BET) inhibitor JQ1 inhibits PD-1 expression in Jurkat T cells, primary T cells, and a T cell exhaustion model. Furthermore, JQ1 dramatically impaired the expression of PD-1 and T cell immunoglobulin mucin-domain-containing-3 (Tim-3), and promoted the secretion of cytokines in T cells from patients with acute myeloid leukemia (AML). Overall design: Gene expression analysis of Jurkat T cells treated with DMSO and JQ1 in the absence or presence of PHA