1Adjusted for multiple comparisons (using false discovery rate)2SNP rs3126085 not in Hardy-Weinberg equilibrium3 X chromosome gene, females only4Risk Allele Score: sum of risk allele counts for each o

Figshare2015-12-03 更新30

An Integrated Data Driven Approach to Drug Repositioning Using Gene-Disease Associations

药物重定位

疾病关联分析

Drug development is both increasing in cost whilst decreasing in productivity. There is a general acceptance that the current paradigm of R&D needs to change. One alternative approach is drug repositi

NIAID Data Ecosystem80

Rare SNVs identified with amino acid changes and computational predictions of pathogenicity.

遗传变异致病性

疾病关联分析

1)PolyPhen2 scores close to 1 are likely to be pathogenic (highlighted in bold). HumDiv-trained Polyphen-2 assumes even mildly deleterious alleles as damaging to evaluate rare alleles potentially invo

Figshare2015-12-02 更新40