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Pervasive transcription-dependent chromatin remodeling influences the replication initiation program

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE111058
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We report here the importance of pervasive transcription in the regulation of replication origins activity in S. cerevisiae. Replication profiles and chromatin profiles were obtained by BrdU-seq and MNase-seq respectively. BrdU-seq was performed 70min after release from G1-phase at 18°C in Nrd1-AA, Nrd1-AA dSet2 and Ysh1-AA strains. MNase-seq was performed after 1h of Rapamycin treatment in Nrd1-AA cells.
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2019-01-02
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