Shank2

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and social behavior. Located in several cellular components, including dendritic spine; photoreceptor inner segment; and photoreceptor outer segment. Colocalizes with neurofilament and postsynaptic membrane. Is expressed in cerebellum; cerebral cortex; frontal cortex; neocortex; and neocortex region. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Nov 2024]

该数据集激活了离子型谷氨酸受体结合活性。涉及多个过程，包括学习或记忆、化学突触传递的调节以及社会行为。存在于多个细胞成分中，如树突棘、光感受器内节段和光感受器外节段。与神经丝和突触后膜共定位。在脑干、大脑皮层、额叶皮层、新皮层及新皮层区域中表达。用于研究自闭症谱系障碍。该基因的人类同源基因与自闭症相关联。与人类SHANK2（SH3和多个ankyrin重复结构域2）同源。[由基因组资源联盟提供，2024年11月]