cyp_p450_2c19_inhibition_veith_et_al

## Dataset Details

### Dataset Description

The CYP P450 genes are essential in the breakdown (metabolism) of
various molecules and chemicals within cells. A drug that can inhibit these
enzymes would mean poor metabolism to this drug and other drugs, which could lead
to drug-drug interactions and adverse effects. Specifically, the CYP2C19 gene
provides instructions for making an enzyme of the endoplasmic reticulum, which
is involved in protein processing and transport.

- **Curated by:**
- **License:** CC BY 4.0

### Dataset Sources

- [corresponding publication](https://doi.org/10.1038/nbt.1581)
- [data source](https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-2c19-inhibition-veith-et-al)

## Citation

**BibTeX:**

```bibtex
@article{Veith2009,
doi = {10.1038/nbt.1581},
url = {https://doi.org/10.1038/nbt.1581},
year = {2009},
month = oct,
publisher = {Springer Science and Business Media LLC},
volume = {27},
number = {11},
pages = {1050--1055},
author = {Henrike Veith and Noel Southall and Ruili Huang and Tim James
and Darren Fayne and Natalia Artemenko and Min Shen and James Inglese
and Christopher P Austin and David G Lloyd and Douglas S Auld},
title = {Comprehensive characterization of cytochrome P450 isozyme selectivity
across chemical libraries},
journal = {Nature Biotechnology}
```

# 数据集详情

## 数据集描述
细胞色素P450（CYP P450）基因是细胞内多种分子与化学物质分解（代谢）过程的必需基因。若某药物可抑制此类酶，则会导致该药物与其他药物的代谢不良，进而引发药物相互作用与不良反应。具体而言，CYP2C19基因负责编码内质网的一种酶，该酶参与蛋白质的加工与转运过程。

- **整理方：**
- **许可协议：** CC BY 4.0

## 数据集来源
- [相关研究文献](https://doi.org/10.1038/nbt.1581)
- [数据集来源](https://tdcommons.ai/single_pred_tasks/adme/#cyp-p450-2c19-inhibition-veith-et-al)

## 引用信息
### BibTeX格式引用
bibtex
@article{Veith2009,
doi = {10.1038/nbt.1581},
url = {https://doi.org/10.1038/nbt.1581},
year = {2009},
month = oct,
publisher = {Springer Science and Business Media LLC},
volume = {27},
number = {11},
pages = {1050--1055},
author = {Henrike Veith and Noel Southall and Ruili Huang and Tim James
and Darren Fayne and Natalia Artemenko and Min Shen and James Inglese
and Christopher P Austin and David G Lloyd and Douglas S Auld},
title = {Comprehensive characterization of cytochrome P450 isozyme selectivity
across chemical libraries},
journal = {Nature Biotechnology}
}