Transcriptome signature of local native cattle of Ladakh region from high altitude and Sahiwal cattle from low altitude (sea level).

The transcriptome signature of peripheral blood mononuclear cells (PBMCs) of Ladakhi cattle adapted to high altitude vis a vis Sahiwal cattle adapted to the arid/semi-arid region at mean sea level was established using bovine expression microarray chips. The transcriptome analysis of PBMCs from these cattle types living at two distinct altitudes, resulted in identification of several hundred differentially expressed genes, biological processes, molecular functions and pathways. The study has utilized Agilent 4x44K bovine chip using single colour matrix to generate transcriptome data of Ladakhi cattle from high altitude and Sahiwal cattle from low altitude arid/semi-arid region.