Table_1_Discipline in Stages: Regulating CD8+ Resident Memory T Cells.pdf

Resident memory CD8+ T (TRM) cells are a lymphocyte lineage distinct from circulating memory CD8+ T cells. TRM lodge within peripheral tissues and secondary lymphoid organs where they provide rapid, local protection from pathogens and control tumor growth. However, dysregulation of CD8+ TRM formation and/or activation may contribute to the pathogenesis of autoimmune diseases. Intrinsic mechanisms, including transcriptional networks and inhibitory checkpoint receptors control TRM differentiation and response. Additionally, extrinsic stimuli such as cytokines, cognate antigen, fatty acids, and damage signals regulate TRM formation, maintenance, and expansion. In this review, we will summarize knowledge of CD8+ TRM generation and highlight mechanisms that regulate the persistence and responses of heterogeneous TRM populations in different tissues and distinct microenvironments.

居民记忆CD8+ T（TRM）细胞是一类与循环记忆CD8+ T细胞相区别的淋巴细胞谱系。TRM细胞驻留于外周组织和次级淋巴器官之中，在这些部位提供对病原体的快速、局部防护并控制肿瘤生长。然而，CD8+ TRM形成和/或激活的失调可能参与自身免疫性疾病的发病机制。内源性机制，包括转录网络和抑制性检查点受体，调控TRM的分化和反应。此外，外源性刺激如细胞因子、同源抗原、脂肪酸和损伤信号调节TRM的形成、维持和扩增。在本综述中，我们将总结CD8+ TRM生成方面的知识，并突出调节不同组织及不同微环境中异质TRM群体持久性和反应的机制。