Toluene/Water Partition Coefficient Database

In recent years the use of partition systems other than the widely used biphasic <em>n</em>-octanol/water has received increased attention to gain insight into the molecular features that dictate the lipophilicity of compounds. Thus, the difference between <em>n</em>-octanol/water and toluene/water partition coefficients has proven to be a valuable descriptor to study the propensity of molecules to form intramolecular hydrogen bonds and exhibit chameleon-like properties that modulate solubility and permeability. In this context, a dataset of <strong>252 unique molecules</strong> with experimentally determined <strong>toluene/water partition coefficient</strong> is deposited here.