Information S1 - A Genome-Wide Association Study of Total Bilirubin and Cholelithiasis Risk in Sickle Cell Anemia

Description of the Bayesian hierarchical model used to create the phenotype in the CSSCD cohort. Supplementary Figure 1 contains information on the LD structure of the UGT1A region in the CSCCD cohort. Supplementary Table 1 contains information on the analysis of the association between bilirubin and after adjusting for our most significant SNP. Figure 1: LD Structure in CSSCD Cohort. LD plots for regions in genes UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9 and UGT1A10 on chromosome 2 in the CSSCD subjects. The LD plot was generated using Haploview 4.2. Each diamond represents the r2 value between two SNPs. The LD color scheme is: white r2 = 0, 02<1 grey (the darker the shade of grey, the higher the r2 value), black r2 = 1.
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