Bulk RNAseq analysis of the terminal ileum from C57BL6N mice, either wild type of mice harbouring a mutation in the Gucy2c gene

The experiment was designed to detemine changes in gene expression between wild type mice and mice with a mutation in receptor guanylyl cyclase C at the Serine 839 position converted to an Isoleucine. This mutation mimics the mutation seen in human patients with familial GUCY2C diarrhoea syndrome.