Expression data from livers of 15-weeks garlic-fed mice

Garlic is a popular flavor enhancer in modern cuisines. Although anti-atherosclerotic, anti-proliferative, hypolipidemic and chemopreventative effects of garlic are known for a long time, the mechanisms of garlic as a dietary supplement ramain largely unknown. We used microarrays to analyze the global programme of gene expression in the liver tissues of control (cellulose) and garlic-fed C57BL/6J mice maintained at an SPF (Specific Pathogen Free) facility. 8-week old male C57BL/6J mice were divided into two diet groups and maintained at a barrier facility (SPF). Mice were fed (ad libitum) a special diet (Yeh and Yeh, 1994) with 4% cellulose (Control group, 3 mice) or 4% lyophilized raw garlic powder (Treatment group, 3 mice). At the end of the 15-week treatment, liver organs were used for RNA isolation and arraying.