Methylation frequency and mean level of methylation in low/intermediate- and high-grade tumour groups.

Number and percentage of low/intermediate- and high-grade tumours that are methylated for each of the six candidate genes (left side of table) and the mean level of methylation in each cohort for each of the gene (right side of table). Methylation is defined using four standard deviations above the mean of the normal bladder controls as a cut-off, as described previously[4]. Differences in the number of tumours methylated comparing high- to low/intermediate-grade tumours were assessed using Fisher’s exact or Chi-squared tests (two-tailed), where p<0.05 is considered significant. Differences in mean methylation were assessed by Students t test, p<0.05 again considered significant.
Methylation frequency and mean level of methylation in low/intermediate- and high-grade tumour groups.