Effect of TGFbeta inibition on the transcriptional profile of aged hematopoietic stem and progenitor cells

The TGFbeta signalling pathway was found to be enriched in aged bone marrow. Here we treated aged mice (24-25 months) with TGFbeta inhibitor to investigate the gene expression of hematopoietic stem and progenitor cells while TGFbeta signalling is inhibited. Overall design: Examine the gene expression profile of hematopoietic stem and progenitor cells (LSK population) in the bone marrow of aged (24-25 months) mice treated with either vehicle or Tgfb1 inhibitor (SB) by single cell RNA-seq