Glycine metabolism
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Glycine is degraded via three pathways. The predominant pathway in animals and plants is the reverse of the glycine synthase pathway. In this context, the enzyme system involved is usually called the glycine cleavage system. In the second pathway, glycine is degraded in two steps. The first step is the reverse of glycine biosynthesis from serine with serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase. In the third pathway of glycine degradation, glycine is converted to glyoxylate by D-amino acid oxidase. Glyoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate in an NAD+-dependent reaction. Description source: [https://en.wikipedia.org/wiki/Glycine#Metabolism Wikipedia]
甘氨酸通过三条途径进行降解。在动物和植物中，主要的降解途径是甘氨酸合成酶途径的逆反应。在此背景下，涉及的酶系统通常被称为甘氨酸裂解系统。在第二条途径中，甘氨酸通过两步降解。第一步是甘氨酸从丝氨酸的生物合成逆反应，此过程中涉及丝氨酸羟甲基转移酶。随后，丝氨酸在丝氨酸脱氢酶的作用下转化为丙酮酸。在甘氨酸降解的第三条途径中，甘氨酸在D-氨基酸氧化酶的作用下转化为甘露醇酸。甘露醇酸随后在肝乳酸脱氢酶的作用下，通过NAD+依赖性反应被氧化为草酸。描述来源：[https://en.wikipedia.org/wiki/Glycine#Metabolism Wikipedia]
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