Modelling Multi-Dimensional ClinOmics for Precision Therapy of Children and Adolescent Young Adults with Relapsed and Refractory Cancer: A Report from the Center for Cancer Research

The Center for Cancer Research (CCR), of the intramural NCI undertook a multidimensional clinical genomics study of children and adolescent young adults with relapsed and refractory cancers who were enrolled on other therapeutic trials to determine the feasibility of a genome guided precision therapy protocol in these patients.Note: NCIPM001blood - This sample was previously submitted with study phs002207, with sample ID NCIPM001blood_E and SRR ID SRR18544311.]]>
The study was comprised of a unique cohort of 59 pediatric patients with solid tumors outside of the central nervous system (CNS) who presented to the National Institutes of Health (NIH) from 2010 to December 2014. Patients had to have matched tumor/normal DNA and RNA available for analysis to qualify for the study.]]>
In this pilot study we performed a multi-dimensional comprehensive genomics analysis of patients referred to the Pediatric Oncology Branch of the NCI's Center for Cancer Research. This included whole exome sequencing (WES) and whole transcriptome sequencing (WTS) of the tumor and WES of matched germline DNA with high density single nucleotide polymorphism (SNP) array analysis of tumor.]]>