Crystal structure of human Sirt2 in complex with a brominated 2nd generation SirReal inhibitor and NAD+
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Crystal structure of human Sirt2 in complex with a brominated 2nd generation SirReal inhibitor and NAD+ Descriptor: N-{5-[(7-bromonaphthalen-1-yl)methyl]-1,3-thiazol-2-yl}-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide, NAD-dependent protein deacetylase sirtuin-2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Rumpf, T, Gerhardt, S, Einsle, O, Jung, M. Deposit date: 2015-09-24 Release date: 2016-01-13 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study. J.Med.Chem., 59, 2016
创建时间：
2015-09-24
