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Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide

NIAID Data Ecosystem2026-05-01 收录

胶质瘤靶向治疗

表观遗传调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE234320 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-06-17

表观遗传调控

青春期启动机制

It has been widely recognized that the early or delayed puberty appears to display harmful effects on adult health outcomes. During the timing of puberty, pituitaries responds to the hypothalamus and

NIAID Data Ecosystem30

Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells

胶质瘤靶向治疗

RNA结合蛋白调控

RNA binding proteins have emerged as critical oncogenic factors and potential targets in cancer therapy. In this study, we evaluated Musashi1 (Msi1) targeting as a strategy to treat glioblastoma (GBM)

NIAID Data Ecosystem10

A semidominant point mutation of Mediator tail subunit MED5b in Arabidopsis leads to altered enrichment of H3K27me3 and reduced expression of targets of MYC2 [RNA-seq]

表观遗传调控

转录因子调控网络

The Mediator complex coordinates regulatory input for transcription driven by RNA Polymerase II in eukaryotes. reduced epidermal fluorescence4-3 (ref4-3) is a semidominant mutation that results in a s

NIAID Data Ecosystem00

Additional file 8 of Molecular basis of high temperature-induced bolting in lettuce revealed by multi-omics analysis

植物高温响应

表观遗传调控

Additional file 8. Overlap between DEGs and DMR-associated genes during high temperature treatment at 8 day.

Figshare2024-02-06 更新10

H4K16 acylations fine-tune transcriptional response to short-chain acyl-CoA dehydrogenase deficiency (ATAC-seq)

表观遗传调控

代谢疾病机制

We investigated the combined effects of H4K16 acylations in vivo using a mouse model of short-chain acyl-CoA dehydrogenase deficiency (SCADD), which causes metabolic challenges and systemic shifts in

NIAID Data Ecosystem00

Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide

资源简介：

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