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Mutant IDH inhibits HNF4a to disrupt hepatocyte differentiation and promote cholangiocarcinoma.

ChEBI2014-04-30 更新2026-07-21 收录

胆管癌发病机制

IDH突变信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-57002 数据链接链接失效反馈

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Mutant IDH inhibits HNF4a to disrupt hepatocyte differentiation and promote cholangiocarcinoma.

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创建时间：

2014-04-30

胆管癌发病机制

单细胞转录组学

Intrahepatic cholangiocarcinoma (ICC) is known to have a poor prognosis among primary liver cancers. We created a mouse model of cholangiocarcinogenesis by specifically deleting Pten and Traf3 in the

NIAID Data Ecosystem70

Expression data from murine intrahepatic biliary organoids. Expression data from murine intrahepatic biliary organoids

胆管癌发病机制

IDH1突变功能

Mutations of isocitrate dehydrogenase (IDH) 1 or 2 occur in 10-30% of intrahepatic cholangiocarcinomas (ICCs). However, their functional roles in biliary carcinogenesis are still unknown. We used micr

NIAID Data Ecosystem60

Concurrent activation of Kras and canonical Wnt pathways induces extrahepatic biliary cancer via premalignant lesions in mice

胆管癌发病机制

癌前病变分子机制

We revealed that concurrent activation of the Kras and canonical Wnt pathways resulted in formation of ICPN and BilIN, which could develop into biliary cancer.

NIAID Data Ecosystem40

Supplementary table S8 from Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma

肠道微生物组与癌症

胆管癌发病机制

16s rRNA sequencing of PSC patients

NIAID Data Ecosystem60

Potential role of inflammation promoting biliary microbiome in primary sclerosing cholangitis and cholangiocarcinoma

胆道微生物群

胆管癌发病机制

This is the first study to investigate both bile and stool microbiota profiles in PSC and CCA, mostly perihilar CCA. Samples with less than 2,000 reads were excluded from the compositional analysis to

NIAID Data Ecosystem50

Mutant IDH inhibits HNF4a to disrupt hepatocyte differentiation and promote cholangiocarcinoma.

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