miR-106 microRNAs bind PTEN mRNA

MicroRNA miR-106b-5p, one of the two mature products of miR-106b, binds the 3'UTR of PTEN mRNA (Poliseno et al. 2010). miR-106b causes reduction in both PTEN mRNA and protein levels and is thus shown to function as a part of the endonucleolytic RISC. It is possible that miR-106b also functions as a part of the nonendonucleolytic RISC. MicroRNA miR-106a-5p, one of the two mature products of miR-106a, is homologous to miR-106b and binds to the 3'UTR of PTEN mRNA. miR-106a presumably functions in a manner similar to miR-106b (Tay et al. 2011).

MicroRNA miR-106b-5p，作为miR-106b的两个成熟产物之一，与PTEN mRNA（3'非编码区）结合（Poliseno等，2010年）。miR-106b导致PTEN mRNA及蛋白质水平降低，从而证实其作为内切核酸酶RISC（RNA干扰复合体）的一部分发挥作用。有可能miR-106b亦作为非内切核酸酶RISC的一部分发挥作用。MicroRNA miR-106a-5p，miR-106a的两个成熟产物之一，与miR-106b同源，并绑定至PTEN mRNA的3'非编码区。据推测，miR-106a的功能方式与miR-106b相似（Tay等，2011年）。