Rhodium-Catalyzed Directed C–H Cyanation of Arenes with N-Cyano‑N‑phenyl‑p‑toluenesulfonamide
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A Rh-catalyzed directed C–H cyanation reaction was developed for the first time as a practical method for the synthesis of aromatic nitriles. N-Cyano-N-phenyl-p-toluenesulfonamide, a user-friendly cyanation reagent, was used in the transformation. Many different directing groups can be used in this C–H cyanation process, and the reaction tolerates a variety of synthetically important functional groups.
创建时间:
2016-02-19



