SprE Levels Are Growth Phase Regulated in a ς(S)-Dependent Manner at the Level of Translation

SprE regulates ς(S) levels in response to nutrient availability by promoting ClpXP-mediated degradation. Paradoxically, we observe that SprE is similarly regulated, accumulating preferentially upon starvation. This regulation of SprE levels is ς(S) dependent, altering SprE synthesis at the level of translation. Thus, we demonstrate that SprE and ς(S) function within a regulatory feedback loop.