Key input parameters in the model.

arates were calculated based on relative risk of mortality per smoking status [25], 2002 Canadian life tables, and 2010 mortality estimates, Statistics Canada (See Appendix S2).bwere estimated based on the symptom rates among smokers, previous smokers, and never smokers reported by Mannino et al [36] for men and women and also proportion of patients without COPD reported by Buist et al [9].cEstimated based on the reported rates for men and women in Buist et al [9] (See Appendix S2).dEstimated based on COPD specific mortality rate of 30.4 per 10,000 (Camp et al [12]) and probabilities of major exacerbations.eEstimated based on progression rates in Hoogendoorn et al [31] (See Appendix S2).fthese weights are EQ-5D Scores.gCosts in in Mannino et al [36] were multiplied by 1.155 to reflect the changes in Canadian Consumer Price Index (CPI) between 2002 and 2011.hEstimated based on proportion of major/minor exacerbations used in Spencer et al [13].