首页/数据集/Analysis of mutational escape and robustness from synthetic TEVp dependent control in Senecavirus A

Analysis of mutational escape and robustness from synthetic TEVp dependent control in Senecavirus A

NIAID Data Ecosystem2026-05-02 收录

病毒逃逸机制

病毒工程改造

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP594599 数据链接链接失效反馈

官方服务：

资源简介：

We engineer Senecavirus A polyprotein processing to be dependent on an orthogonal protease TEVp, and then analyze the resulting mutational pressure and mechanisms of escape when delivered in vivo.

应用场景：

创建时间：

2025-06-27

病毒逃逸机制

宿主-病原体相互作用

Noroviruses are a leading cause of gastroenteritis worldwide, yet the molecular mechanisms of how host antiviral factors restrict norovirus infection are poorly understood. Here we present a CRISPR ac

NIAID Data Ecosystem80

Cap-independent translation and a precisely localized RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response. Cap-independent translation and a precisely localized RNA sequence enable SARS-CoV-2 to control host translation and escape anti-viral response

病毒逃逸机制

帽非依赖性翻译

Translation of SARS-CoV-2-encoded mRNAs by the host ribosomes is essential for its propagation. Following infection, the early expressed viral protein NSP1 binds the ribosome, represseses translation

NIAID Data Ecosystem50

Profiling of escape kinetics of viruses subjected to RNAi

病毒逃逸机制

RNA干扰抗病毒机制

To assess how viruses of different genome compositions escape engineered RNAi Overall design: mRNA profiles and alignments to viral genomes of BHK-21, RNaseIII-/-, and MDCK cells infected with Sindbis

NIAID Data Ecosystem40

Table_6_RNA 2’-O-Methyltransferase Fibrillarin Facilitates Virus Entry Into Macrophages Through Inhibiting Type I Interferon Response.xlsx

病毒逃逸机制

RNA修饰与免疫

Type I interferons (IFN-I) play crucial roles in antiviral immune responses through inducing multiple antiviral interferon stimulated genes (ISGs). RNA modifications are emerging as critical post-tran

NIAID Data Ecosystem70

Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants

免疫分子识别

病毒逃逸机制

Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 index peptide and three of its escape variants Descriptor: Beta-2-microglobulin, Glyco

Protein Data Bank Japan2024-10-16 更新50

Analysis of mutational escape and robustness from synthetic TEVp dependent control in Senecavirus A

资源简介：

相关数据集