Data of multiple different high-fat diets

Background and Objectives: The spectrum of non-alcoholic fatty liver disease (NAFLD), known as non-alcoholic steatohepatitis (NASH), can lead to advanced liver disease. It is known that a variety of diets play a significant role in the development of NAFLD/NASH. The goal of this study is to determine the most appropriate composition of diet to induce NASH in an animal model.
Methods: This research used Rattus norvegicus strain Wistar (n=27), which were divided into four groups and given each diet for 12 weeks: normal diet (ND, n=7), high-fat diet (HFD, n=6), Western diet (WD, n=7), high-fat-high-fructose diet (HFHFD, n=7). Subjects were documented for body weight. Blood samples were taken for biochemical analysis: low-density lipoprotein (LDL), triglyceride, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), hepatic lipase, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and lipopolysaccharide (LPS). Feces were taken for short-chain ..., The Ethical Committee of the Faculty of Medicine, Universitas Brawijaya reviewed and approved all procedures (No. 66/EC/KEPK/02/2021). Twenty seven male Wistar rats were obtained from the Universitas Gadjah Mada. Rat inclusion criteria included: male rat with shiny white fur, healthy, active, and have normal behavior; about 8–12 weeks old; the average body weight was 150–180 grams. Exclusion criteria included: the appearance of dull fur, loss and baldness; less or inactive activity; rats that during the study did not want to eat; weight loss >10% after adaptation period; Disabled, sick and/or dead rat. In minimizing pain and discomfort to experimental animals, this research uses the refinement principle for ensuring the welfare of experimental animals until the end of the study. We provided food and drink regularly every day with a certain type of diet according to the type of treatment. Cage maintenance, cage cleaning, and husk replacement were carried out every day with attention t..., Software that is required to open the data files in format .sav is SPSS.