Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor
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https://figshare.com/articles/dataset/Highly_Diastereoselective_Synthesis_of_a_HCV_NS5B_Nucleoside_Polymerase_Inhibitor/7443377
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资源简介：
An
asymmetric synthesis of HCV NS5B nucleoside polymerase inhibitor
(1) is described. This novel route features several remarkably
diastereoselective and high-yielding transformations, including construction
of the all-carbon quaternary stereogenic center at C-2 via a thermodynamic
aldol reaction. A subsequent glycosylation reaction with activated
uracil via C-1 phosphate and installation of the cyclic phosphate
group using an achiral phosphorus(III) reagent followed by oxidation
provides 1.
创建时间：
2018-12-10
