Environmental effects on muonium adducts of lidocaine using avoided level crossing muon spin resonance

Lidocaine is a local anaesthetic, identified by the World Health Organisation as an essential medicine. In order to reach its site of action, lidocaine first has to pass from a watery environment outside a cell, through at least one cell membrane, the inside of which is oily. Water and oil are known not to mix, yet lidocaine traverses both! Although much is known about the interaction of lidocaine with membranes, typically this has been done with bulky labels that may affect the membrane. Muons, a type of subatomic particle, are able to interact with substances with certain structural features. Muons themselves weigh around 1/9 that of a proton and thus can act as ultrasensitive labels while not perturbing the system. This proposal explores how the signal generated by the interaction of lidocaine with muons is affected by its environment, including the effect of pH and solvent polarity.利多卡因（Lidocaine）是一种局部麻醉剂，被世界卫生组织（World Health Organization，WHO）列为基本药物。为抵达其作用靶点，利多卡因需先从细胞外的水环境穿过至少一层细胞膜——细胞膜内部为疏水环境。众所周知水与油不相溶，但利多卡因却可同时跨越这两种介质。尽管学界对利多卡因与细胞膜的相互作用已有较多研究，但过往相关实验通常使用体积庞大的标记物，这类标记物可能会对细胞膜造成干扰。μ子（Muons）作为一类亚原子粒子，可与具备特定结构特征的物质发生相互作用。μ子的质量约为质子的1/9，因此可作为超灵敏标记物，且不会对研究体系造成扰动。本研究拟探讨利多卡因与μ子相互作用产生的信号如何受所处环境影响，其中包括pH值与溶剂极性的作用效果。

搜集汇总

背景与挑战

背景概述

该数据集通过避免能级交叉μ子自旋共振技术，研究利多卡因（一种局部麻醉药）的μ子加合物在不同环境条件（如pH和溶剂极性）下的行为，使用μ子作为超灵敏标签以最小化系统扰动。数据来自ISIS中子与μ子源的实验（编号RB2010608），以RAW/Nexus格式发布，适用于分析环境因素对药物跨膜传输机制的影响。