Enriched marine oils supplements increase peripheral blood SPM concentrations and reprogram host immune responses: A randomized double-blind placebo-controlled study

The aim of the present study was to establish the relationship(s) between supplement dose using a novel enriched marine oil preparation, peripheral blood SPM concentrations and cellular responses. We also aimed to assess the kinetics for these responses in order to provide 1) insights into the protective mechanisms activated by omega-3 supplements in humans and 2) novel potential biomarkers for determining the effectiveness of omega-3 supplements at regulating host immune responses. Double blinded, crossover, placebo-controlled study in 22 healthy volunteers: Using RNA sequencing we assessed the diferential gene expresion between patients from the placebo and marine oil supplementation groups.