Crystal structure of BACE1 in complex with hydroxyethylamine inhibitor 37
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Crystal structure of BACE1 in complex with hydroxyethylamine inhibitor 37 Descriptor: (2R)-N-{(2S,3R)-4-{[(4'S)-6'-(2,2-dimethylpropyl)-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl]amino}-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl}-2-methoxypropanamide, Beta-secretase 1, GLYCEROL Authors: Whittington, D.A, Long, A.M. Deposit date: 2012-01-30 Release date: 2012-10-10 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (2 Å) Cite: Design and synthesis of potent, orally efficacious hydroxyethylamine derived beta-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors. J.Med.Chem., 55, 2012
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2012-01-30
