Disease-stratified relative risks of death for the ApoE4 carriers compared to the non-carriers in the more homogeneous group of the FHS and FHSO participants with lifespans of 70 to 95 years.

*Individuals with missing neurodegenerative disorders (ND) status were excluded in all models.
CVD = cardiovascular diseases; Cancer includes all sites but skin; Non-prostate indicates non-skin cancers apart from prostate neoplasm in men; Non-breast indicates non-skin cancers apart from breast neoplasm in women;
RR = relative risk; CI = Confidence interval; Ntotal and Ndied denote the total number of genotyped individuals and the number of deaths among them, respectively.
All models were adjusted for birth cohorts, an indicator of the FHS or FHSO, and additive contribution of CVD, ND, and cancer, as applicable, e.g., the model for samples stratified by CVD was adjusted by cancer and ND.