Signaling suppressive determinants of the FGFR2 C-terminus

The constitutive activation of C-terminally truncated FGFR2 triggers MAPK and PI3K–AKT–mTOR signaling pathways. However, it has remained unclear, which adaptor proteins mediate oncogenic FGFR2-dE18 signaling. It has also remained unresolved, which motifs or amino acid residues within the C-terminal tail are most critical to suppress oncogenic FGFR2 signaling. Here we made us of a compendium of Fgfr2-dE18 and Fgfr2 C-terminal variants to functionally dissect FGFR2-dE18 signaling and the tumor suppressive nature of the FGFR2 C-terminus.