Structure of human PKCBeta Kinase domain with Ruboxistaurin, D427N mutant

Structure of human PKCBeta Kinase domain with Ruboxistaurin, D427N mutant Descriptor: (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, Isoform Beta-II of Protein kinase C beta type Authors: Briggs, D.C, Parker, P.J, McDonald, N.Q, Brown, S.J. Deposit date: 2025-08-06 Release date: 2025-11-05 Last modified: 2025-12-24 Method: X-RAY DIFFRACTION (3.425 Å) Cite: Penetrant PKC beta mutation in ATLL displays a mixed gain-of-function. Biochem.J., 482, 2025