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Chip-chip from THP1 and HUVEC cells with ROR-alpha

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE94079
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ROR-alpha is a nuclear receptor, activity of which can be modulated by natural or synthetic ligands including cholesterol. Due to its possible involvement in, and potential therapeutic target for atherosclerosis, we aimed to identify ROR-alpha target genes in monocyte and endothelial cell lines, THP1 and HUVEC, respectively. ChIP-on-chip analysis of ROR-alpha demonstrated that ROR-alpha may target more than 3000 genes in monocytic and endothelial cells. Comparison of DNA immunoprecipated with anti-ROR-alpha antibody vs DNA immunoprecipated with anti-IgG antibody from CGP52608 treated cells.
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2017-03-05
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