Biochemical characterization, biosynthesis mechanism, and functional evaluation of selenium-enriched Aspergillus oryzae A02

Selenium-enriched A. oryzae A02 was observed to primarily upregulate peroxisome activity while downregulating estrogen 2-hydroxylase activity in mice hepatocytes, suggesting its potential in fortifying antioxidant physiological functions and upholding metabolic balance. To assess the regulatory impact of selenium-enriched A. oryzae A02 on mice metabolism and scrutinize its potential regulatory mechanisms, we administered selenium-enriched A. oryzae A02 to mice for 8 weeks and scrutinized its effects on growth performance and liver physiological metabolism.