CHEK1 phosphorylates TP53
收藏reactome.org2025-01-15 收录
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CHEK1, activated by ATR-mediated phosphorylation, can phosphorylate TP53 at serine residue S20, resulting in the increased half-life of TP53 (Shieh et al. 2000).
CHEK1(检查点1)蛋白,由ATR介导的磷酸化激活,能够磷酸化TP53蛋白的丝氨酸残基S20,从而使得TP53蛋白的半衰期延长(Shieh等,2000年)。
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