Modulation of behavioral and hippocampal transcriptomic responses in rat prolonged chronic unpredictable stress model by fluoxetine, eicosapentaenoic acid and lipopolysaccharide. Modulation of behavioral and hippocampal transcriptomic responses in rat prolonged chronic unpredictable stress model by fluoxetine, eicosapentaenoic acid and lipopolysaccharide

Here, we examine behavioral and brain transcriptomic (RNA-seq) responses in rat prolonged chronic unpredictable stress (PCUS) model, and their modulation by 4-week treatment with fluoxetine, eicosapentaenoic acid (EPA), lipopolysaccharide (LPS) and their combinations. Overall design: Comparative gene expression profiling analysis of RNA-seq data for hippocampus of wistar male rats (n=3) subjected to 12 weeks of chronic unpredictable stress (CUS; 1) or rats also subjected to fluoxetine (2), lipopolysacharide (3), eicosapentaenoic acid (4), fluoxetine + eicosapentaenoic acid (5), and fluoxetine + lipopolysacharide (6) for last 4 weeks of CUS or experimentally naive rats (7).