List of genes significantly upregulated in lethal prostate cancer and highly confidently associcated with NFκB in multiple biological contexts.

We integrated 860 total datasets (651 gene expression datasets and 225 gene interaction networks) using a Bayesian framework in different biological contexts (including cell death, cell differentiation, cell cycle, cell proliferation, cell migration, and NFκB regulation; S3 Table). From such context-specific networks, we extracted the subnetworks of genes most confidently associated with NFκB (S5 Table), which were subsequently analyzed in a differential expression study for significant (FDR corrected p.05) changes between lethal and indolent prostate cancer (see Methods); this resulted in eight total genes.