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The crystal structure of the 2009 H1N1 PA endonuclease wild type in complex with SJ000988632

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Protein Data Bank Japan2023-10-25 更新2026-03-21 收录
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The crystal structure of the 2009 H1N1 PA endonuclease wild type in complex with SJ000988632 Descriptor: 1,1',1'',1''',1''''-[(3R,5S,7S,9R)-decane-1,3,5,7,9-pentayl]penta(pyrrolidin-2-one), MANGANESE (II) ION, N-[2-(6-amino-9H-purin-9-yl)ethyl]-5-hydroxy-6-oxo-2-[2-(trifluoromethyl)phenyl]-1,6-dihydropyrimidine-4-carboxamide, ... Authors: Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. Deposit date: 2019-12-13 Release date: 2021-02-10 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
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2019-12-13
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